Which marker is used in immunohistochemical staining to identify tumors of epithelial origin?

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Study for the Stevens Immunology-Serology Test. Hone your skills with flashcards and multiple choice questions, each enriched with hints and explanations. Prepare confidently for your exam now!

Multiple Choice

Which marker is used in immunohistochemical staining to identify tumors of epithelial origin?

Explanation:
Epithelial tumors show cytokeratins, a family of intermediate filament proteins found in most epithelial cells. Immunohistochemical staining for cytokeratins highlights cells of epithelial origin, pointing toward carcinoma and helping distinguish it from tumors of mesenchymal or hematopoietic lineage. In contrast, vimentin marks mesenchyme, CD45 marks leukocytes, and CD10 is less specific for epithelial tumors. Using cytokeratin staining (often a pan-cytokeratin panel like AE1/AE3) is the standard way to identify epithelial origin.

Epithelial tumors show cytokeratins, a family of intermediate filament proteins found in most epithelial cells. Immunohistochemical staining for cytokeratins highlights cells of epithelial origin, pointing toward carcinoma and helping distinguish it from tumors of mesenchymal or hematopoietic lineage. In contrast, vimentin marks mesenchyme, CD45 marks leukocytes, and CD10 is less specific for epithelial tumors. Using cytokeratin staining (often a pan-cytokeratin panel like AE1/AE3) is the standard way to identify epithelial origin.

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