Which autoantibodies are most strongly linked to Wegener's granulomatosis?

Which autoantibodies are most strongly linked to Wegener's granulomatosis?

• A. ANA
• B. ANCA
• C. AMA
• D. SMA

Answer: (A)

Autoantibodies associated with granulomatosis with polyangiitis are ANCA, especially the c-ANCA pattern directed against proteinase 3 (PR3-ANCA). This antibody is the most characteristic serologic finding for GPA and supports the diagnosis when clinical features fit. In contrast, ANA targets nuclear components and is common in diseases like lupus but is not specifically linked to GPA. AMA and SMA are associated with autoimmune liver diseases (primary biliary cholangitis and autoimmune hepatitis, respectively) and have no strong connection to GPA. So the strongest link is ANCA, particularly c-ANCA/PR3-ANCA.

Autoantibodies associated with granulomatosis with polyangiitis are ANCA, especially the c-ANCA pattern directed against proteinase 3 (PR3-ANCA). This antibody is the most characteristic serologic finding for GPA and supports the diagnosis when clinical features fit. In contrast, ANA targets nuclear components and is common in diseases like lupus but is not specifically linked to GPA. AMA and SMA are associated with autoimmune liver diseases (primary biliary cholangitis and autoimmune hepatitis, respectively) and have no strong connection to GPA. So the strongest link is ANCA, particularly c-ANCA/PR3-ANCA.