Th17 cells affect the innate immune response by inducing production of which cytokines?

Th17 cells affect the innate immune response by inducing production of which cytokines?

• A. IFN-γ and IL-2
• B. IL-4 and IL-10
• C. IL-2 and IL-4
• D. TNF-α and IL-6

Answer: (D)

Th17 cells help connect adaptive and innate immunity by driving innate inflammatory signals. They produce IL-17, which acts on macrophages, epithelial, and stromal cells to trigger the release of pro-inflammatory mediators. Among these, TNF-α and IL-6 are key cytokines that amplify inflammation, promote fever, and recruit neutrophils, strengthening the innate response to pathogens. The other cytokine pairs belong to different T helper profiles (Th1 or Th2) and don’t capture this specific link to innate inflammatory amplification. So the cytokines induced in this context are TNF-α and IL-6.

Th17 cells help connect adaptive and innate immunity by driving innate inflammatory signals. They produce IL-17, which acts on macrophages, epithelial, and stromal cells to trigger the release of pro-inflammatory mediators. Among these, TNF-α and IL-6 are key cytokines that amplify inflammation, promote fever, and recruit neutrophils, strengthening the innate response to pathogens. The other cytokine pairs belong to different T helper profiles (Th1 or Th2) and don’t capture this specific link to innate inflammatory amplification. So the cytokines induced in this context are TNF-α and IL-6.